Counteracting tumor radioresistance by targeting DNA repair

Counteracting tumor radioresistance by targeting DNA repair.

The power of ionizing radiation as a therapeutic modality is based in large part on two basic principles. One is the use of sophisticated delivery systems that minimize the dose to normal tissues and maximize the dose to the tumor, an approach epitomized by the advent of intensity-modulated radiation therapy. Intensitymodulated radiation therapy harnesses sophisticated three-dimensional compute...

Targeting DNA Damage and Repair by Curcumin

Curcumin is a compound with anti-tumor effects in a tolerable dose. A recent paper by Rowe et al described that curcumin induced DNA damage in triple negative breast cancer cells and regulated BRCA1 protein expression and modification.1 Related research and potential use of curcumin will be discussed in this article.

Radiation Induced Radioresistance – Role of DNA Repair and Mitochondria

The DNA repair function of CUX1 contributes to radioresistance

Ionizing radiation generates a broad spectrum of oxidative DNA lesions, including oxidized base products, abasic sites, single-strand breaks and double-strand breaks. The CUX1 protein was recently shown to function as an auxiliary factor that stimulates enzymatic activities of OGG1 through its CUT domains. In the present study, we investigated the requirement for CUX1 and OGG1 in the resistance...

miR-620 promotes tumor radioresistance by targeting 15-hydroxyprostaglandin dehydrogenase (HPGD)

MicroRNA contribute to tumor radiation resistance, which is an important clinical problem, and thus we are interested in identifying and characterizing their function. We demonstrate that miR-620 contributes to radiation resistance in cancer cells by increasing proliferation, and decreasing the G2/M block. We identify the hydroxyprostaglandin dehydrogenase 15-(nicotinamide adenine dinucleotide)...